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Particle Deposition in Human Lungs

인체내 입자점착에 대한 수학모형을 개발하고, 객체, 입자, 환경특성을 고려한 흡수선량 (dosimetry)을 예측하여 대기오염에 따른 인체유해성 평가를 하고자 한다.

A dynamic single-path mathematical model was developed that is capable of analyzing detailed deposition patterns of inhaled particles in human lungs. Weibel’s symmetric lung morphology was adopted as the basic lung structure, and detailed transport processes were evaluated numerically using the fully implicit procedure. Deposition efficiencies by specific mechanisms were individually examined for accuracy and new empirical formulas were incorporated whenever appropriate. Deposition in the alveolar region was divided into deposition fractions in the alveolar duct and alveoli considering active transport processes between the two regions. The deposition fractions were obtained for each airway generation, serial lung volumetric compartments, and conventional three-compartment anatomic lung regions. In addition, the surface dose and cumulative deposition with time were analyzed. The results showed excellent agreement with available experimental data. The present model provides an improvement from the previously reported models and can be used as a tool in assessing internal dose of inhaled particles under various inhalation conditions.

Choi & Kim (2007) Inhalation Toxicology

Schematic diagram of one-dimensional trumpet morphology of human lungs.

Schematic diagram of particle transport and deposition processes in the alveolar region: (a) inspiration and (b) expiration.

Total deposition fraction vs. particle diameter in the normal lung at FRC = 3000 ml for three different breathing patterns.

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